Comparing the SARS-CoV-2-specific antibody response in human milk after homologous and heterologous booster vaccinations.

ABSTRACT: Human milk contains SARS-CoV-2-specific antibodies after COVID-19 vaccination. These milk antibodies decrease several months post-vaccination. Whether booster immunization restores human milk antibody levels, potentially offering prolonged passive immunity for the infant, remains unknown. In this prospective follow-up study, we investigated the longitudinal SARS-CoV-2-specific antibody response in human milk of 26 lactating women who received a COVID-19 booster dose of an mRNA-based vaccine. Moreover, we evaluated whether the booster-induced human milk antibody response differs for participants who received a similar or different vaccine type in their primary vaccination series. All participants (100%) who received a homologous booster vaccination showed SARS-CoV-2-specific immunoglobulin

SUBMITTER: Mulleners SJ 

PROVIDER: S-EPMC9875178 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature