Peripheral blood lymphocytes differentiation patterns in responses / outcomes to immune checkpoint blockade therapies in non-small cell lung cancer: a retrospective study.

ABSTRACT:

Objectives

Programmed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for the therapeutic efficacy of PD-L1 and PD-1 blockade remain elusive.

Materials and methods

For a comprehensive analysis of peri-treatment lymphocyte differentiation, in the current study, we enrolled 146 non-small cell lung cancer patients who received α-PD-1 therapies for exploring the peripheral blood lymphocyte differentiation pattern at baseline and post-treatment (dynamic changes) by flow cytometry.

Results

At baseline, CD4⁺ / CD8⁺ T cell ratio predicts good responses and outcomes, but activated T cell and cytotoxic T cell counts pre

SUBMITTER: Du X 

PROVIDER: S-EPMC9875514 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature