Time-restricted eating did not alter insulin sensitivity or β-cell function in adults with obesity: A randomized pilot study.

ABSTRACT:

Objective

Decreased insulin sensitivity and impairment of β-cell function predate and predict development of type 2 diabetes mellitus. Time-restricted eating (TRE) might have a benefit for these parameters. The objective of this pilot study was to investigate this possibility.

Methods

Secondary analysis of a randomized controlled trial comparing 12 weeks of TRE (8-hour eating window) to unrestricted eating (non-TRE) was performed. Participants were adults with overweight or obesity and without diabetes. Two-hour oral glucose tolerance testing was performed at baseline and end-intervention. Glucose tolerance test-derived measures of insulin sensitivity, insulin secretion, and β-cell function were compared between groups.

Results

Participants (17 women/3 men with mean [

SUBMITTER: Bantle AE 

PROVIDER: S-EPMC9877119 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature