Pharmacokinetic profile of acyclovir in a child receiving continuous kidney replacement therapy for acute liver failure.

ABSTRACT:

Background

Continuous venovenous hemodiafiltration (CVVHDF) is one of the treatments of critically ill children presenting severe acute liver failure. This affliction might be induced by HSV infection requiring a treatment by acyclovir. Continuous kidney replacement therapy (CKRT) can alter its pharmacokinetics, according to its physicochemical properties and CVVHDF settings.

Case-diagnosis/treatment

The patient was a 21-month-old female presenting liver failure with hyperammonemia treated by acyclovir with presumed HSV infection. CKRT was initiated on day 1 with substantial replacement and dialysate flow rates (respectively 75 and 220 mL/kg/h). Acyclovir was intravenously administered every 8 h with a 1-h infusion of 500 mg/m². Plasma and effluent concentrations

SUBMITTER: Collignon C 

PROVIDER: S-EPMC9880359 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature