Developmental trajectories of thalamic progenitors revealed by single-cell transcriptome profiling and Shh perturbation.

ABSTRACT: The thalamus is the principal information hub of the vertebrate brain, with essential roles in sensory and motor information processing, attention, and memory. The complex array of thalamic nuclei develops from a restricted pool of neural progenitors. We apply longitudinal single-cell RNA sequencing and regional abrogation of Sonic hedgehog (Shh) to map the developmental trajectories of thalamic progenitors, intermediate progenitors, and post-mitotic neurons as they coalesce into distinct thalamic nuclei. These data reveal that the complex architecture of the thalamus is established early during embryonic brain development through the coordinated action of four cell differentiation lineages derived from Shh-dependent and -independent progenitors. We systematically characterize the gene exp

SUBMITTER: Govek KW 

PROVIDER: S-EPMC9880597 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature