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Genetic footprints of assortative mating in the Japanese population.

ABSTRACT: Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits in the Japanese population using BioBank Japan Project genome-wide association studies data (n = 172,270), we found evidence of AM on the liability to type 2 diabetes and coronary artery disease, as well as on dietary habits. In cross-population comparison using United Kingdom Biobank data (n = 337,139) we found shared but heterogeneous impacts of AM between populations.

SUBMITTER: Yamamoto K

PROVIDER: S-EPMC9883156 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Genetic footprints of assortative mating in the Japanese population.

Yamamoto Kenichi K Sonehara Kyuto K Namba Shinichi S Konuma Takahiro T Masuko Hironori H Miyawaki Satoru S Kamatani Yoichiro Y Hizawa Nobuyuki N Ozono Keiichi K Yengo Loic L Okada Yukinori Y

Nature human behaviour 20220922 1

Assortative mating (AM) is a pattern characterized by phenotypic similarities between mating partners. Detecting the evidence of AM has been challenging due to the lack of large-scale datasets that include phenotypic data on both partners, especially in populations of non-European ancestries. Gametic phase disequilibrium between trait-associated alleles is a signature of parental AM on a polygenic trait, which can be detected even without partner data. Here, using polygenic scores for 81 traits ...[more]

PMID: 36138222

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