Identification and functional analysis of N6-methyladenine (m⁶ A)-related lncRNA across 33 cancer types.

ABSTRACT:

Background

N6-methyladenosine (m⁶ A) plays an essential role in tumorigenesis and cancer progression. Long noncoding RNAs (lncRNAs) are discovered to be important targets of m⁶ A modification, and they play fundamental roles in diverse biological processes. However, there is still a lack of knowledge with regards to the association between m⁶ A and lncRNAs in human tumors.

Methods

The relationship between lncRNAs and 21 m⁶ A regulators was comprehensively explored, through the integration of multi-omics data from M6A2Target, m6A-Atlas, and TCGA (The Cancer Genome Atlas). In order to explore the potential roles of m6A-related lncRNAs in human tumors, three applicable methods were introduced, which include the construction of ceRNA n

SUBMITTER: Xu D 

PROVIDER: S-EPMC9883401 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature