Low ferroptosis score predicts chemotherapy responsiveness and immune-activation in colorectal cancer.

ABSTRACT:

Background

Existing studies for ferroptosis and prognosis in colorectal cancer (CRC) were limited. In this study, we aim to investigate the prognostic role of ferroptosis markers in patients with CRC and exploration of its micro-environmental distributions.

Methods

Immunohistochemical staining was performed for CRC patients' tissue microarray. Selection and prognostic validation of markers were based on mRNA data from the cancer genome atlas (TCGA) database. Gene Set Enrichment Analysis (GSEA) was performed to indicate relative immune landmarks and hallmarks. Ferroptosis and immune contexture were examined by CIBERSORT. Survival outcomes were analyzed by Kaplan-Meier analysis and cox analysis.

Results

A panel of 42 genes was selected. Through mRNA expression differenc

SUBMITTER: Lv Y 

PROVIDER: S-EPMC9883409 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature