Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth.

ABSTRACT:

Background

Prenatal cadmium (Cd) exposure has been implicated in both placental toxicity and adverse neurobehavioral outcomes. Placental microRNAs (miRNAs) may function to developmentally program adverse pregnancy and newborn health outcomes in response to gestational Cd exposure.

Methods

In a subset of the Rhode Island Child Health Study (RICHS, n = 115) and the New Hampshire Birth Cohort Study (NHBCS, = 281), we used small RNA sequencing and trace metal analysis to identify Cd-associated expression of placental miRNAs using negative binomial generalized linear models. We predicted mRNAs targeted by Cd-associated miRNAs and relate them to neurobehavioral outcomes at birth through the integration of transcriptomic data and summary scores from the NICU Network Neurobehavioral

SUBMITTER: Tehrani JM 

PROVIDER: S-EPMC9884320 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature