Prediction of venous thromboembolism incidence in the general adult population using two published genetic risk scores.

ABSTRACT:

Introduction

Most strategies for prevention of venous thromboembolism focus on preventing recurrent events. Yet, primary prevention might be possible through approaches targeting the whole population or high-risk patients. To inform possible prevention strategies, population-based information on the ability of genetic risk scores to identify risk of incident venous thromboembolism is needed.

Materials and methods

We used proportional hazards regression to relate two published genetic risk scores (273-variants versus 5-variants) with venous thromboembolism incidence in the Atherosclerosis Risk in Communities Study (ARIC) cohort (n = 11,292), aged 45-64 at baseline, drawn from 4 US communities.

Results

Over a median of 28 years, ARIC identified 788 incident venous throm

SUBMITTER: Folsom AR 

PROVIDER: S-EPMC9886242 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature