Long-term outcomes in distinct phenogroups of patients with primary mitral regurgitation undergoing valve surgery.

ABSTRACT:

Objectives

Patients with mitral regurgitation (MR) may be heterogeneous with different risk profiles. We aimed to identify distinct phenogroups of patients with severe primary MR and investigate their long-term prognosis after mitral valve (MV) surgery.

Methods

The retrospective cohort of patients with severe primary MR undergoing MV surgery (derivation, n=1629; validation, n=692) was analysed. Latent class analysis was used to classify patients into subgroups using 15 variables. The primary outcome was all-cause mortality after MV surgery.

Results

During follow-up (median 6.0 years), 149 patients (9.1%) died in the derivation cohort. In the univariable Cox analysis, age, female, atrial fibrillation, left ventricular (LV) end-systolic dimension/volumes, LV ejection fr

SUBMITTER: Kwak S 

PROVIDER: S-EPMC9887360 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature