Epigenetic aging in patients diagnosed with coronary artery disease: results of the LipidCardio study.

ABSTRACT:

Introduction

People age biologically at different rates. Epigenetic clock-derived DNA methylation age acceleration (DNAmAA) is among the most promising markers proposed to assess the interindividual differences in biological age. Further research is needed to evaluate the characteristics of the different epigenetic clock biomarkers available with respect to the health domains they reflect best.

Methods

In this study, we have analyzed 779 participants of the LipidCardio study (mean chronological age 69.9 ± 11.0 years, 30.6% women) who underwent diagnostic angiography at the Charité University Hospital in Berlin, Germany. DNA methylation age (DNAm age) was measured by methylation-sensitive single nucleotide primer extension (MS-SNuPE) and calculated with the 7-CpG clock. We co

SUBMITTER: Banszerus VL 

PROVIDER: S-EPMC9887837 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature