Oligodendrocyte precursor cells ingest axons in the mouse neocortex.

ABSTRACT: Neurons in the developing brain undergo extensive structural refinement as nascent circuits adopt their mature form. This physical transformation of neurons is facilitated by the engulfment and degradation of axonal branches and synapses by surrounding glial cells, including microglia and astrocytes. However, the small size of phagocytic organelles and the complex, highly ramified morphology of glia have made it difficult to define the contribution of these and other glial cell types to this crucial process. Here, we used large-scale, serial section transmission electron microscopy (TEM) with computational volume segmentation to reconstruct the complete 3D morphologies of distinct glial types in the mouse visual cortex, providing unprecedented resolution of their morphology and composition

SUBMITTER: Buchanan J 

PROVIDER: S-EPMC9889886 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature