PLX3397, a CSF1 receptor inhibitor, limits allotransplantation-induced vascular remodelling.

ABSTRACT:

Aims

Graft vascular disease (GVD), a clinically important and highly complex vascular occlusive disease, arises from the interplay of multiple cellular and molecular pathways. While occlusive intimal lesions are composed predominantly of smooth-muscle-like cells (SMLCs), the origin of these cells and the stimuli leading to their accumulation in GVD are uncertain. Macrophages have recently been identified as both potential drivers of intimal hyperplasia and precursors that undergo transdifferentiation to become SMLCs in non-transplant settings. Colony-stimulating factor-1 (CSF1) is a well-known regulator of macrophage development and differentiation, and prior preclinical studies have shown that lack of CSF1 limits GVD. We sought to identify the origins of SMLCs and of cells express

SUBMITTER: Almonte VM 

PROVIDER: S-EPMC9890458 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature