syn-Elimination of glutamylated threonine in lanthipeptide biosynthesis.

ABSTRACT: Methyllanthionine (MeLan) containing macrocycles are key structural features of lanthipeptides. They are formed typically by anti-elimination of L-Thr residues followed by cyclization of L-Cys residues onto the (Z)-dehydrobutyrine (Dhb) intermediates. In this report we demonstrate that the biosynthesis of lanthipeptides containing the D-allo-L-MeLan macrocycle such as the morphogenetic lanthipeptide SapT proceeds through (E)-Dhb intermediates formed by net syn-elimination of L-Thr.

SUBMITTER: Sarksian R 

PROVIDER: S-EPMC9890492 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature