Transcriptome-wide association study identifies novel genes associated with bone mineral density and lean body mass in children.

ABSTRACT:

Objective

To identify novel candidate genes whose expression is associated with bone mineral density (BMD) and body lean mass (LM) in children.

Methods

A tissue-specific transcriptome-wide association study (TWAS) was conducted utilizing a large-scale genome-wide association study (GWAS) dataset associated with BMD and LM and involving 10,414 participants. The measurement of BMD and LM phenotypes was made based on total-body dual-energy X-ray absorptiometry (TB-DXA) scans. TWAS was conducted by using FUSION software. Reference panels for muscle skeleton (MS), peripheral blood (NBL) and whole blood (YBL) were used for TWAS analysis. Functional enrichment and protein-protein interaction (PPI) analyses of the genes identified by TWAS were performed by using the online tool Meta

SUBMITTER: Xu J 

PROVIDER: S-EPMC9892108 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature