A systematic review and Bayesian meta-analysis of the antibiotic treatment courses in AECOPD.

ABSTRACT: Background: No consensus exists on the antibiotic treatment course for patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Former studies indicate that shorter courses might have the same efficacy with fewer adverse events, which is inconsistent with guidelines and general practice. Existing evidence allows us to conduct a systematic review and Bayesian analysis on this topic. Methods: Four databases were searched from their inception to January 5, 2023. All statistical estimations were performed using R. "Gemtc" was the core package of analysis. CINeMA was used to assess the grade of confidence of the results. Results: Fourteen studies were included in the Bayesian meta-analysis. No difference in the clinical success rate of ant

SUBMITTER: Yu H 

PROVIDER: S-EPMC9895851 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature