Association of 2 Lysyl Oxidase Gene Single Nucleotide Polymorphisms with Keratoconus: A Nationwide Registration Study.

ABSTRACT:

Purpose

Keratoconus (KC) is the most common primary ectatic corneal disease, characterized by progressive thinning of the cornea, affecting its shape and structure and leading to visual loss. Lysyl oxidase is an important component of the extracellular matrix and contributes to the homeostasis of corneal stromal extracellular matrix via enzymatic reaction. This nationwide registration study aims to examine the association of KC with 2 known single nucleotide polymorphisms, rs2956540 and rs10519694, in a population of Iranian descent.

Design

Case-control.

Participants

One hundred seventy-eight subjects with KC and 180 clinically healthy subjects participated in the study.

Methods

Genomic DNA was extracted from peripheral blood samples, and their genotypes were d

SUBMITTER: Niazi S 

PROVIDER: S-EPMC9898806 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature