Cancer functional states-based molecular subtypes of gastric cancer.

ABSTRACT:

Background

The treatment of gastric cancer remains a challenge.

Methods

We divided gastric cancer into three subtypes based on 14 cancer functional states. We investigated differences between subtypes through multi-omics data, especially at the single-cell level, which allowed us to analyze differences from the perspective of each type of cell rather than the whole.

Results

The cluster 1 is characterized by high levels of tumor progression-related cancer functional status, worst survival outcomes, low metabolic level, high infiltration of immunosuppressive cells, high copy number variations (CNV), and low tumor mutational burden (TMB). The cluster 2 is characterized by low levels of tumor progression-related cancer functional status, favorable prognosis, moderate meta

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9899380 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature