Zebrafish Tric-b is required for skeletal development and bone cells differentiation.

ABSTRACT:

Introduction

Trimeric intracellular potassium channels TRIC-A and -B are endoplasmic reticulum (ER) integral membrane proteins, involved in the regulation of calcium release mediated by ryanodine (RyRs) and inositol 1,4,5-trisphosphate (IP₃Rs) receptors, respectively. While TRIC-A is mainly expressed in excitable cells, TRIC-B is ubiquitously distributed at moderate level. TRIC-B deficiency causes a dysregulation of calcium flux from the ER, which impacts on multiple collagen specific chaperones and modifying enzymatic activity, leading to a rare form of osteogenesis imperfecta (OI Type XIV). The relevance of TRIC-B on cell homeostasis and the molecular mechanism behind the disease are still unknown.

Results

In this study, we exploited zebrafish to elucidate the r

SUBMITTER: Tonelli F 

PROVIDER: S-EPMC9899828 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature