CD103 fate mapping reveals that intestinal CD103^- tissue-resident memory T cells are the primary responders to secondary infection.

ABSTRACT: Tissue-resident memory T (T_RM) cells remain poised in the tissue and mediate robust protection from secondary infection. T_RM cells within the intestine and other tissues are heterogeneous in their phenotype and function; however, the contributions of these T_RM subsets to secondary infection remain poorly defined. To address the plasticity of intestinal T_RM subsets and their role in local and systemic immunity, we generated mice to fate map intestinal CD103⁺ T_RM cells and track their location and function during secondary infection with Yersinia pseudotuberculosis. We found that CD103⁺ T_RM cells remained lodged in the tissue and were poorly reactivated during secondary challenge. CD103^-

SUBMITTER: Fung HY 

PROVIDER: S-EPMC9901738 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature