Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.

ABSTRACT:

Background

Naturally occurring germline gene deletions (KO) represent a unique setting to interrogate gene functions. Complete deletions and differential expression of the human glycosyltransferase UGT2B17 and UGT2B28 genes are linked to prostate cancer (PCa) risk and progression, leukaemia, autoimmune and other diseases.

Methods

The systemic metabolic consequences of UGT deficiencies were examined using untargeted and targeted mass spectrometry-based metabolomics profiling of carefully matched, treatment-naive PCa cases.

Results

Each UGT KO differentially affected over 5% of the 1545 measured metabolites, with divergent metabolic perturbations influencing the same pathways. Several of the perturbed metabolites are known to promote PCa growth, invasion and metastasis,

SUBMITTER: Rouleau M 

PROVIDER: S-EPMC9902621 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature