Multi-omics data reveals the important role of glycerophospholipid metabolism in the crosstalk between gut and brain in depression.

ABSTRACT:

Background

Gut microbiota plays a critical role in the onset and development of depression, but the underlying molecular mechanisms are unclear. This study was conducted to observe the characteristics of gut microbiota, lipid metabolism and neurotransmitters in Gut-Liver-Brain axis in depressed mice (DM), and identify some novel perceptions on relationships between gut microbiota and depression.

Methods

A mouse model of depression was built used chronic unpredictable mild stress (CUMS). Fecal samples (measuring gut microbiota compositions, microbial genes and lipid metabolites), liver samples (measuring lipid metabolites), and hippocampus (measuring neurotransmitters) were collected. Both univariate and multivariate statistical analyses were used to identify the differential

SUBMITTER: Xie J 

PROVIDER: S-EPMC9903503 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature