Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer.

ABSTRACT: Obesity and obesity-driven cancer rates are continuing to rise worldwide. We hypothesize that adipocyte-colonocyte interactions are a key driver of obesity-associated cancers. To understand the clinical relevance of visceral adipose tissue in advancing tumor growth, we analyzed paired tumor-adjacent visceral adipose, normal mucosa, and colorectal tumor tissues as well as presurgery blood samples from patients with sporadic colorectal cancer. We report that high peroxisome proliferator-activated receptor gamma (PPARG) visceral adipose tissue expression is associated with glycoprotein VI (GPVI) signaling-the major signaling receptor for collagen-as well as fibrosis and adipogenesis pathway signaling in colorectal tumors. These associations were supported by correlations between PPA

SUBMITTER: Holowatyj AN 

PROVIDER: S-EPMC7877796 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature