Isolation, characterization, and docking studies of campesterol and β-sitosterol from Strychnos innocua (Delile) root bark.

ABSTRACT:

Objectives

Phytosterols obtained from medicinal plants are well known for their anti-diabetic, anti-cardiovascular, anti-cancer, and anti-microbial properties. Strychnos innocua (a member of the Loganiaceae family) grows in several African nations and is frequently used for medicinal purposes.

Methods

The chromatographic separation of S. innocua (root bark) ethyl acetate extract resulted in the isolation of campesterol (1) and β-sitosterol (2).

Results

The structures of 1 and 2 were confirmed by mass spectrometry, nuclear magnetic resonance (1D and 2D NMR), and literature data. This is a novel report of campesterol and β-sitosterol from S. innocua. Docking studies revealed that the binding affinities of 1 with th

SUBMITTER: Uttu AJ 

PROVIDER: S-EPMC9906018 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature