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Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse.

ABSTRACT: Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.

SUBMITTER: Ntinginya NE 

PROVIDER: S-EPMC9907486 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Tuberculosis Molecular Bacterial Load Assay Reveals Early Delayed Bacterial Killing in Patients With Relapse.

Ntinginya Nyanda Elias NE   Bakuli Abhishek A   Mapamba Daniel D   Sabiiti Wilber W   Kibiki Gibson G   Minja Lilian Tina LT   Kuchaka Davis D   Reither Klaus K   Phillips Patrick Peter John PPJ   Boeree Martin Johan MJ   Gillespie Stephen H SH   Hoelscher Michael M   Heinrich Norbert N  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20230201 3

Bacterial killing in patients with tuberculosis (TB) relapse was compared to that in patients achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time to positivity (TTP). TB-MBLA in 4 relapsed patients was significantly different compared to 132 cured patients after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8. ...[more]

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