Long-term outcomes of patients with normal fractional flow reserve and thin-cap fibroatheroma.

ABSTRACT:

Background

The long-term prognostic implications of fractional flow reserve (FFR)-negative lesions hosting vulnerable plaques remain unsettled.

Aims

The aim of this study was to evaluate the association of non-ischaemic lesions hosting optical coherence tomography (OCT)-detected thin-cap fibroatheromas (TCFA) with first and recurrent cardiovascular events during follow-up up to 5 years in a diabetes mellitus (DM) patient population.

Methods

COMBINE OCT-FFR is a prospective, international, double-blind, natural history study. Patients with DM and with ≥1 FFR-negative lesion were classified into 2 groups based on the presence or absence of ≥1 TCFA lesion. The primary endpoint (PE) is a composite of cardiac mortality, target vessel-related myocardial infarction (TV-MI),

SUBMITTER: Fabris E 

PROVIDER: S-EPMC9909454 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature