FGL2-targeting T cells exhibit antitumor effects on glioblastoma and recruit tumor-specific brain-resident memory T cells.

ABSTRACT: Although tissue-resident memory T (T_RM) cells specific for previously encountered pathogens have been characterized, the induction and recruitment of brain T_RM cells following immune therapy has not been observed in the context of glioblastoma. Here, we show that T cells expressing fibrinogen-like 2 (FGL2)-specific single-chain variable fragments (T-αFGL2) can induce tumor-specific CD8⁺ T_RM cells that prevent glioblastoma recurrence. These CD8⁺ T_RM cells display a highly expanded T cell receptor repertoire distinct from that found in peripheral tissue. When adoptively transferred to the brains of either immunocompetent or T cell-deficient naïve mice, these CD8⁺ T_RM cells reject glioma cells. Mechanistic

SUBMITTER: Zhao Q 

PROVIDER: S-EPMC9911733 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature