Dataset Information

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

ABSTRACT:

Background

We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer.

Methods

Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database (2010-2017) were included. A generalized logistic model was used to identify factors associated with surgery type. A Kaplan-Meier curve was used to visualize unadjusted OS, and the log-rank test was used to test for differences in OS between surgery types.

Results

Of 597,149 patients, 58% underwent lumpectomy with radiation (BCT), 25% unilateral mastectomy (UM), and 17% bilateral mastectomy (BM). After adjustment, HER2+ and triple-negative (TN) tumors were less likely to undergo UM than BCT, versus hormone receptor-positive tumors (OR = 0.881, 95% CI = 0.860-0.903; OR = 0.485, 95% CI = 0.470-0.501). UM and BM had worse 5-year OS versus BCT (UM: 0.926, vs BM: 0.952, vs BCT: 0.960).

Conclusions

BCT is increasingly used to treat HER2+ and TN tumors. More extensive surgery is not associated with better survival outcomes, regardless of tumor phenotype.

SUBMITTER: Rooney MM

PROVIDER: S-EPMC9912362 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Rooney Marguerite M MM Thomas Samantha M SM Taskindoust Mahsa M Greenup Rachel A RA Rosenberger Laura H LH Hwang E Shelley ES Plichta Jennifer K JK

American journal of surgery 20220922 1

<h4>Background</h4>We investigated whether tumor phenotype influences surgical decision-making, and how that may impact overall survival (OS) for early-stage breast cancer.<h4>Methods</h4>Women aged 18-69 with cT0-2/cN0/cM0 breast cancer in the National Cancer Database (2010-2017) were included. A generalized logistic model was used to identify factors associated with surgery type. A Kaplan-Meier curve was used to visualize unadjusted OS, and the log-rank test was used to test for differences in ...[more]

PMID: 36180300

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Dataset Information

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

Background

Methods

Results

Conclusions

Publications

The role of tumor phenotype in the surgical treatment of early-stage breast cancer.

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