Ketamine and esketamine in suicidal thoughts and behaviors: a systematic review.

ABSTRACT:

Background

More than 2% of the general population experience suicidal ideas each year and a large number of them will attempt suicide. Evidence-based therapeutic options to manage suicidal crisis are currently limited.

Objectives

The aim of this study was to overview the findings on the use of ketamine and esketamine for the treatment of suicidal ideas and acts.

Design

Systematic review.

Data sources and methods

PubMed, article references, and Clinicaltrials.gov up to June 30, 2022. Meta-analyses published within the last 2 years were also reviewed.

Results

We identified 12 randomized controlled trials with reduction of suicidal ideation as the primary objective and 14 trials as secondary objectives. Intravenous racemic ketamine was superior to control d

SUBMITTER: Jollant F 

PROVIDER: S-EPMC9912570 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature