Cartilage tissue turnover increases with high- compared to low-intensity resistance training in patients with knee OA.

ABSTRACT:

Objectives

To investigate cartilage tissue turnover in response to a supervised 12-week exercise-related joint loading training program followed by a 6-month period of unsupervised training in patients with knee osteoarthritis (OA). To study the difference in cartilage tissue turnover between high- and low-resistance training.

Method

Patients with knee OA were randomized into either high-intensity or low-intensity resistance supervised training (two sessions per week) for 3 months and unsupervised training for 6 months. Blood samples were collected before and after the supervised training period and after the follow-up period. Biomarkers huARGS, C2M, and PRO-C2, quantifying cartilage tissue turnover, were measured by ELISA. Changes in biomarker levels over time within and be

SUBMITTER: Thudium CS 

PROVIDER: S-EPMC9912672 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature