Uterine Cavity Lavage Mutation Analysis in Lithuanian Ovarian Cancer Patients.

ABSTRACT:

Background

Type II ovarian cancer (OC) is generally diagnosed at an advanced stage, translating into a poor survival rate. Current screening methods for OC have failed to demonstrate a reduction in mortality. The uterine lavage technique has been used to detect tumor-specific TP53 mutations from cells presumably shed from high-grade serous ovarian cancer (HGSOC). We aimed to pilot whether the detection of TP53 mutation in uterine cavity lavage can be used as a diagnostic method for HGSOC using an expanded gene panel.

Methods

In this study 90, uterine lavage and 46 paired biopsy samples were analyzed using next-generation sequencing (NGS) targeting TP53 as well as five additional OC-related genes: BRCA1, BRCA2, PI3KCA, PTEN, an

SUBMITTER: Zilovic D 

PROVIDER: S-EPMC9913062 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature