Dataset Information

Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank.

ABSTRACT:

Objective

This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex.

Methods

In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail individuals categorized by sex.

Results

Lower concentrations of apoA1, total, LDL, and HDL cholesterol, albumin, eGFRcys, vitamin D, total bilirubin, apoB, and testosterone (differences ranged from -0.30 to -0.02 per 1-SD change), as well as higher concentrations of triglycerides, GGT, cystatin C, CRP, ALP, and phosphate (differences ranged from 0.01 to 0.53 per 1-SD change), were identified both in pre-frail and frail men and women. However, some of the associations differed by sex. For instance, higher rheumatoid factor and urate concentrations were identified in pre-frail and frail women, while lower calcium, total protein, and IGF-1 concentrations were identified in pre-frail women and frail women and men. When the analyses were further adjusted for CRP, similar results were found.

Conclusions

Several biomarkers were linked to pre-frailty and frailty. Nonetheless, some of the associations differed by sex. Our findings contribute to a broader understanding of the pathophysiology of frailty as currently defined.

SUBMITTER: Chu W

PROVIDER: S-EPMC9915970 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank.

Chu Wenying W Lynskey Nathan N Iain-Ross James J Pell Jill P JP Sattar Naveed N Ho Frederick K FK Welsh Paul P Celis-Morales Carlos C Petermann-Rocha Fanny F

International journal of environmental research and public health 20230129 3

<h4>Objective</h4>This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex.<h4>Methods</h4>In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail indivi ...[more]

PMID: 36767787

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Dataset Information

Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank.

Objective

Methods

Results

Conclusions

Publications

Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank.

Similar Datasets

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