Identifying the Biomarker Profile of Pre-Frail and Frail People: A Cross-Sectional Analysis from UK Biobank.

ABSTRACT:

Objective

This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex.

Methods

In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this cross-sectional analysis. Further, 31 biomarkers were investigated in this study. Frailty was defined using a modified version of the Frailty Phenotype. Multiple linear regression analyses were performed to explore the biomarker profile of pre-frail and frail individuals categorized by sex.

Results

Lower concentrations of apoA1, total, LDL, and HDL cholesterol, albumin, eGFRcys, vitamin D, total bilirubin, apoB, and testosterone (differences ranged from -0.30 to -0.02 per 1-SD change), as well as higher concentrations of triglycerides, GGT, cystatin C,

SUBMITTER: Chu W 

PROVIDER: S-EPMC9915970 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature