Overcoming cancer-associated fibroblast-induced immunosuppression by anti-interleukin-6 receptor antibody.

ABSTRACT: Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment and play a central role in tumor progression. Previously, we reported that CAFs might induce tumor immunosuppression via interleukin-6 (IL-6) and promote tumor progression by blocking local IL-6 in the tumor microenvironment with neutralizing antibody. Here, we explore whether an anti-IL-6 receptor antibody could be used as systemic therapy to treat cancer, and further investigate the mechanisms by which IL-6 induces tumor immunosuppression. In clinical samples, IL-6 expression was significantly correlated with α-smooth muscle actin expression, and high IL-6 cases showed tumor immunosuppression. Multivariate analysis showed that IL-6 expression was an independent prognostic factor. In vitro, IL-6 co

SUBMITTER: Nishiwaki N 

PROVIDER: S-EPMC9916502 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature