Hypoxic storage of murine red blood cells improves energy metabolism and post-transfusion recoveries.

ABSTRACT:

Background

The Red blood cell (RBC) storage lesion results in decreased circulation and function of transfused RBCs. Elevated oxidant stress and impaired energy metabolism are a hallmark of the storage lesion in both human and murine RBCs. Although human studies don't suffer concerns that findings may not translate, they do suffer from genetic and environmental variability amongst subjects. Murine models can control for genetics, environment, and much interventional experimentation can be carried out in mice that is neither technically feasible nor ethical in humans. However, murine models are only useful to the extent that they have similar biology to humans. Hypoxic storage has been shown to mitigate the storage lesion in human RBCs, but has not been investigated in mice.

Mate

SUBMITTER: Hay A 

PROVIDER: S-EPMC9918384 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature