A Highly Efficacious Electrical Biofilm Treatment System for Combating Chronic Wound Bacterial Infections.

ABSTRACT: Biofilm infection has a high prevalence in chronic wounds and can delay wound healing. Current treatment using debridement and antibiotic administration imposes a significant burden on patients and healthcare systems. To address their limitations, a highly efficacious electrical antibiofilm treatment system is described in this paper. This system uses high-intensity current (75 mA cm^-2 ) to completely debride biofilm above the wound surface and enhance antibiotic delivery into biofilm-infected wounds simultaneously. Combining these two effects, this system uses short treatments (≤2 h) to reduce bacterial count of methicillin-resistant S. aureus (MRSA) biofilm-infected ex vivo skin wounds from 10¹⁰ to 10^5.2 colony-forming units (CFU) g^-1 . Taking

SUBMITTER: Zhao F 

PROVIDER: S-EPMC9918715 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature