Brain functional network abnormalities in parkinson's disease with mild cognitive impairment.

ABSTRACT: Mild cognitive impairment in Parkinson's disease (PD-M) is related to a high risk of dementia. This study explored the whole-brain functional networks in early-stage PD-M. Forty-one patients with PD classified as cognitively normal (PD-N, n = 17) and PD-M (n = 24) and 24 demographically matched healthy controls (HC) underwent clinical and neuropsychological evaluations and resting-state functional magnetic resonance imaging. The global, regional, and modular topological characteristics were assessed in the brain functional networks, and their relationships to cognitive scores were tested. At the global level, PD-M and PD-N exhibited higher characteristic path length and lower clustering coefficient, local and global efficiency relative to HC. At the regional level, PD-M and PD-N showed low

SUBMITTER: Suo X 

PROVIDER: S-EPMC9923713 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature