Identification of m⁷G regulator-mediated RNA methylation modification patterns and related immune microenvironment regulation characteristics in heart failure.

ABSTRACT:

Background

N⁷-methylguanosine (m⁷G) modification has been reported to regulate RNA expression in multiple pathophysiological processes. However, little is known about its role and association with immune microenvironment in heart failure (HF).

Results

One hundred twenty-four HF patients and 135 nonfailing donors (NFDs) from six microarray datasets in the gene expression omnibus (GEO) database were included to evaluate the expression profiles of m⁷G regulators. Results revealed that 14 m⁷G regulators were differentially expressed in heart tissues from HF patients and NFDs. Furthermore, a five-gene m⁷G regulator diagnostic signature, NUDT16, NUDT4, CYFIP1, LARP1, and DCP2, which can easily distinguish HF patients and NFDs,

SUBMITTER: Ma C 

PROVIDER: S-EPMC9926673 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature