Peptidomics analysis of plasma in patients with ankylosing spondylitis.

ABSTRACT:

Background

This study aimed to explore the differential expression of peptides associated with ankylosing spondylitis (AS) patients, enabling identification of potential functional peptides to provide the basis for the novel intervention targets for AS.

Material and methods

3 AS patients and 3 healthy volunteers were enrolled in this study. The expression profiles for peptides present in the plasma of AS patients and the healthy individual were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The physicochemical properties and biological functions of identified peptides were further analyzed by bioinformatics. The results of peptide identification were verified by cell viability analysis, using CCK8 and Edu staining assay, and the differential peptides

SUBMITTER: Zhang GN 

PROVIDER: S-EPMC9927206 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature