Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model.
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ABSTRACT:
SUBMITTER: Palubeckaite I
PROVIDER: S-EPMC9928768 | biostudies-literature | 2023 Mar
REPOSITORIES: biostudies-literature
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Does PARP Inhibition Sensitize Chondrosarcoma Cell Lines to Chemotherapy or Radiotherapy? Results From a Three-dimensional Spheroid Cell Model.
Palubeckaitė Ieva I Venneker Sanne S van den Akker Brendy E W M BEWM Briaire-de Bruijn Inge H IH Boveé Judith V M G JVMG
Clinical orthopaedics and related research 20221213 3
<h4>Background</h4>Chondrosarcomas are well known for their resistance to conventional chemotherapy and radiotherapy treatment regimens, which is particularly detrimental in patients who have unresectable tumors. Recently, inhibition of poly(ADP-ribose) polymerase (PARP) by talazoparib was shown to sensitize chondrosarcoma cell lines to chemotherapy (temozolomide) or radiotherapy, irrespective of isocitrate dehydrogenase (IDH) mutation status. Because two-dimensionally grown cell lines have limi ...[more]
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