Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese.

ABSTRACT:

Purpose

Nuclear weapons testing in the northern Marshall Islands between 1946 and 1958 resulted in ionizing radiation (IR) exposure of the thousands of Marshallese. Furthermore, numerous islands were contaminated by radioactive fallout. Significant increases in cancer and metabolic syndrome incidences have been reported among Marshallese, and potential for further increases looms due to the latency of radiation-induced health effects. The purpose of this study was to investigate the genetic and epigenetic effects of exposure to IR that could be associated with radiation-induced disease among the Northwest Arkansas (NWA) Marshallese.

Materials and methods

We performed analysis of chromosomal aberrations and DNA methylation based on residential and exposure history of NWA Mars

SUBMITTER: Ewing LE 

PROVIDER: S-EPMC9929030 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature