Janus Self-Propelled Chitosan-Based Hydrogel Spheres for Rapid Bleeding Control.

ABSTRACT: Uncontrolled hemorrhage is a major cause of potentially preventable death in civilian trauma nowadays. Considerable concern has been given to the development of efficient hemostats with high blood absorption, self-propelled property, and Ca²⁺ release ability, for irregularly shaped and noncompressible hemorrhage. Herein, Janus self-propelled chitosan-based hydrogel with CaCO₃ (J-CMH@CaCO₃ ) is developed by partial ionic crosslinking of carboxylated chitosan (CCS) and Ca²⁺ , gravity settlement, and photopolymerization, followed by removing the shell of CCS. The obtained J-CMH@CaCO₃ is further used as a hemostat powered by the internal CaCO₃ and coordinated protonated tranexamic acid (J-CMH@CaCO₃ /T). Bubbles are ge

SUBMITTER: Yu Q 

PROVIDER: S-EPMC9929117 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature