Dataset Information

Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.

ABSTRACT:

Objectives

Cyclooxygenase-2-derived prostaglandin E2 (PGE2) is highly involved in the promotion of cancer progression. The end product of this pathway, PGE-major urinary metabolite (PGE-MUM), is a stable metabolite of PGE2 that can be assessed non-invasively and repeatedly in urine samples. The aim of this study was to assess the dynamic changes in perioperative PGE-MUM levels and their prognostic significance in non-small-cell lung cancer (NSCLC).

Methods

Between December 2012 and March 2017, 211 patients who underwent complete resection for NSCLC were analysed prospectively. PGE-MUM levels in 2 spot urine samples taken 1 or 2 days preoperatively and 3-6 weeks postoperatively were measured using a radioimmunoassay kit.

Results

Elevated preoperative PGE-MUM levels were associated with tumour size, pleural invasion and advanced stage. Multivariable analysis revealed that age, pleural invasion, lymph node metastasis and postoperative PGE-MUM levels were independent prognostic factors. In matched pre- and postoperative urine samples obtained from patients who are eligible for adjuvant chemotherapy, an increase in PGE-MUM levels following resection was an independent prognostic factor (hazard ratio 3.017, P = 0.005). Adjuvant chemotherapy improved survival in patients with increased PGE-MUM levels after resection (5-year overall survival, 79.0 vs 50.4%, P = 0.027), whereas survival benefit was not observed in those with decreased PGE-MUM levels (5-year overall survival, 82.1 vs 82.3%, P = 0.442).

Conclusions

Increased preoperative PGE-MUM levels can reflect tumour progression and postoperative PGE-MUM levels are a promising biomarker for survival after complete resection in patients with NSCLC. Perioperative changes in PGE-MUM levels may aid in determining the optimal eligibility for adjuvant chemotherapy.

SUBMITTER: Mikubo M

PROVIDER: S-EPMC9931073 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.

Mikubo Masashi M Satoh Yukitoshi Y Ono Mototsugu M Sonoda Dai D Hayashi Shoko S Naito Masahito M Matsui Yoshio Y Shiomi Kazu K Matsuura Masaaki M Ito Satoru S

Interdisciplinary cardiovascular and thoracic surgery 20230101 1

<h4>Objectives</h4>Cyclooxygenase-2-derived prostaglandin E2 (PGE2) is highly involved in the promotion of cancer progression. The end product of this pathway, PGE-major urinary metabolite (PGE-MUM), is a stable metabolite of PGE2 that can be assessed non-invasively and repeatedly in urine samples. The aim of this study was to assess the dynamic changes in perioperative PGE-MUM levels and their prognostic significance in non-small-cell lung cancer (NSCLC).<h4>Methods</h4>Between December 2012 an ...[more]

PMID: 36802257

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Dataset Information

Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.

Objectives

Methods

Results

Conclusions

Publications

Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.

Similar Datasets

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