Prognostic implications of prostaglandin E-major urinary metabolite in resected non-small-cell lung cancer.

ABSTRACT:

Objectives

Cyclooxygenase-2-derived prostaglandin E2 (PGE2) is highly involved in the promotion of cancer progression. The end product of this pathway, PGE-major urinary metabolite (PGE-MUM), is a stable metabolite of PGE2 that can be assessed non-invasively and repeatedly in urine samples. The aim of this study was to assess the dynamic changes in perioperative PGE-MUM levels and their prognostic significance in non-small-cell lung cancer (NSCLC).

Methods

Between December 2012 and March 2017, 211 patients who underwent complete resection for NSCLC were analysed prospectively. PGE-MUM levels in 2 spot urine samples taken 1 or 2 days preoperatively and 3-6 weeks postoperatively were measured using a radioimmunoassay kit.

Results

Elevated preoperative PGE-MUM levels wer

SUBMITTER: Mikubo M 

PROVIDER: S-EPMC9931073 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature