Zika virus leads to olfactory disorders in mice by targeting olfactory ensheathing cells.

ABSTRACT:

Background

Zika virus (ZIKV) is an emerging arbovirus of the genus flavivirus that is associated with congenital Zika syndrome (CZS) in newborns. A wide range of clinical symptoms including intellectual disability, speech delay, coordination or movement problems, and hearing and vision loss, have been well documented in children with CZS. However, whether ZIKV can invade the olfactory system and lead to post-viral olfactory dysfunction (PVOD) remains unknown.

Methods

We investigated the susceptibility and biological responses of the olfactory system to ZIKV infection using mouse models and human olfactory organoids derived from patient olfactory mucosa.

Findings

We demonstrate that neonatal mice infected with ZIKV suffer from transient olfactory dysfunction when they

SUBMITTER: Zhou J 

PROVIDER: S-EPMC9931927 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature