Geographic Analysis of the Safety and Efficacy of Filgotinib in Rheumatoid Arthritis.

ABSTRACT:

Introduction

Global clinical trials in rheumatoid arthritis (RA) often do not recruit enough patients from diverse racial and ethnic backgrounds to identify any potential differences in treatment outcome across such groups. To overcome this limitation, using data from five previous clinical trials and two ongoing trial extensions, this study aimed to assess the efficacy and safety of filgotinib in patients with RA across geographic regions.

Methods

This was a post hoc, exploratory analysis of data from male and female patients with RA meeting the 2010 RA criteria as defined by the American College of Rheumatology (ACR) and European Alliance of Associations for Rheumatology. Data were analyzed from phase 2 (DARWIN 1-2) and phase 3 (FINCH 1-3) clinical trials, as well as two l

SUBMITTER: Combe B 

PROVIDER: S-EPMC9931958 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature