Molecular imaging of chemokine-like receptor 1 (CMKLR1) in experimental acute lung injury.

ABSTRACT: The lack of techniques for noninvasive imaging of inflammation has challenged precision medicine management of acute respiratory distress syndrome (ARDS). Here, we determined the potential of positron emission tomography (PET) of chemokine-like receptor-1 (CMKLR1) to monitor lung inflammation in a murine model of lipopolysaccharide-induced injury. Lung uptake of a CMKLR1-targeting radiotracer, [⁶⁴Cu]NODAGA-CG34, was significantly increased in lipopolysaccharide-induced injury, correlated with the expression of multiple inflammatory markers, and reduced by dexamethasone treatment. Monocyte-derived macrophages, followed by interstitial macrophages and monocytes were the major CMKLR1-expressing leukocytes contributing to the increased tracer uptake throughout the first week of lipo

SUBMITTER: Mannes PZ 

PROVIDER: S-EPMC9934297 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature