B cell receptor-induced IL-10 production from neonatal mouse CD19⁺CD43^- cells depends on STAT5-mediated IL-6 secretion.

ABSTRACT: Newborns are unable to reach the adult-level humoral immune response partly due to the potent immunoregulatory role of IL-10. Increased IL-10 production by neonatal B cells has been attributed to the larger population of IL-10-producting CD43⁺ B-1 cells in neonates. Here, we show that neonatal mouse CD43^- non-B-1 cells also produce substantial amounts of IL-10 following B cell antigen receptor (BCR) activation. In neonatal mouse CD43^- non-B-1 cells, BCR engagement activated STAT5 under the control of phosphorylated forms of signaling molecules Syk, Btk, PKC, FAK, and Rac1. Neonatal STAT5 activation led to IL-6 production, which in turn was responsible for IL-10 production in an autocrine/paracrine fashion through the activation of STAT3. In addition to the

SUBMITTER: Sakai J 

PROVIDER: S-EPMC9934864 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature