Tumor-associated macrophage polarization in the inflammatory tumor microenvironment.
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ABSTRACT:
SUBMITTER: Zou Z
PROVIDER: S-EPMC9934926 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
Tumor-associated macrophage polarization in the inflammatory tumor microenvironment.
Zou Zijuan Z Lin Hongfen H Li Mengsen M Lin Bo B
Frontiers in oncology 20230202
The chronic inflammation of tumor continues to recruit TAMs (tumor-associated macrophages) to the TME (tumor microenvironment) and promote polarization. Pro-inflammatory signals polarize macrophages to the M1 phenotype to enhance inflammation against pathogens. Tumor inflammatory development changes the pro-inflammatory response to an anti-inflammatory response, resulting in the alteration of macrophages from M1 to M2 to promote tumor progression. Additionally, hypoxia activates HIF (hypoxia-ind ...[more]
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