Allelic and Genotype Frequencies of CYP2B6^∗2 (64C > T) and CYP2B6^∗3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.

ABSTRACT:

Background

Cytochrome P450 complex plays a key role in drug metabolism. CYP2B6 has an essential part in Cytochrome P450 complex metabolism. This study aims to determine the allelic distribution of CYP2B6^∗2 and CYP2B6^∗3 in three main Iranian ethnicities: Fars, Turk, and Kurd.

Methods

The study was conducted on 174 unrelated healthy volunteers from three main Iranian ethnicities. After DNA extraction from peripheral blood samples, genotyping of CYP2B6^∗2 and ^∗3 was performed using tetra ARMS and ARMS PCR, respectively.

Results

The average age of 174 cases was 40.69 ± 11.87 (mean ± SD) and 39.06 ± 11.63 (mean ± SD) for males and females. In the CYP2B6^∗2 variant, the genotyping frequency of wild type (C/C), heterozygou

SUBMITTER: Khavandegar A 

PROVIDER: S-EPMC9934979 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature