Nanodrug rescues liver fibrosis via synergistic therapy with H₂O₂ depletion and Saikosaponin b1 sustained release.

ABSTRACT: Hypoxia and hydrogen peroxide (H₂O₂) accumulation form the profibrogenic liver environment, which involves fibrogenesis and chronic stimulation of hepatic stellate cells (HSCs). Catalase (CAT) is the major antioxidant enzyme that catalyzes H₂O₂ into oxygen and water, which loses its activity in different liver diseases, especially in liver fibrosis. Clinical specimens of cirrhosis patients and liver fibrotic mice are collected in this work, and results show that CAT decrease is closely correlated with hypoxia-induced transforminmg growth factor β1 (TGF-β1). A multifunctional nanosystem combining CAT-like MnO₂ and anti-fibrosis Saikosaponin b1 (Ssb1) is subsequently constructed for antifibrotic therapy. MnO₂ catalyzes the acc

SUBMITTER: Peng M 

PROVIDER: S-EPMC9935535 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature